How do antipyretics work?
Answer:
Wikipedia give a general description:
"Antipyretics motive the hypothalamus to override an interleukin-induced increase in heat. The body will then work to lower the heat and the result is a reduction within fever." [1]
This other page give some more details, talking almost how different antipyretics inhibit the production of different chemicals that cause the hypothalamus to lift the body temperature setpoint:
"Aspirin and the non-steroidal antiphlogistics display antipyretic flurry by inhibiting the cyclo-oxygenase, an enzyme responsible for the synthesis of PGE (these antipyretics don't inhibit the production of TNF- or IL-1). Glucocorticoids work antipyretically by inhibiting the production of IL-1 and TNF- , and by inhibiting the metabolic processes of arachidonic acid." [2]
Does that facilitate?
Antipyretics work by getting the "thermostat" in the hypothalamus to override the interleukin-induced increase contained by temperature. The body will afterwards work to lower the temperature to the unusual, lower temperature and the result is a narrowing in the restlessness. Antipyretics will also reduce prostaglandin synthesis within the hypothalamus by inhibiting the effect of endogenous or microbial pyrogens on the heat regulating sensors of the hypothalamus. By blocking prostaglandin synthetase, antipyretics prevent a rise contained by prostaglandin levels surrounded by the brain.