Mechanism of ESR?
Answers:
Here is a simplified explaination of why ESR increases as a result of inflammation.
The outside of a red cell is positively charged, generally at indistinguishable level, except surrounded by the middle of the cell (the thinnest part of the biconcave disc) where on earth it is relatively negatively charged. This means that the within is an attraction between this negative charge and the positive charges of other red cell (opposites attract). However, under typical conditions, the positive charges around the rest of the red cell repel the other positive charges of other red cells. This repulsive force is call the Zeta potential. So in the run of the mill state, the Zeta potential is stronger than the attractive force.
During states of inflammation, there are more immunoglobulins, proteins and acute phase reactants sent out into the blood, these are negatively charged, and dwindle the overall Zeta potential, and subsequently the repulsive force. This means that the positive areas on the red cell can now return with closer to the negative nouns of other red cells. And they do so. The outlook of the shape of the red cells technique that they fit quite compactly (with minimal deformity) into each other, and stack close to coins. The more the inflammatory response, the higher the acute phase reactants and other proteins within the blood, and the lower the Zeta potential, the greater the attraction between the red cells, and the difficult the ESR.
Hope this helps
erythrocyte sedimentation rate, can be found on the net, or better yet at wikipedia.
The esr is a exam to measure all along time a column of blood falls in a capillary tube. It turns out that if here is inflammation it falls faster so a higher ESR. It is not specific for a particuar condition it merely shows there is inflammation. When here is inflammation red blood cells certainly stack up like a stack of coins and this is call rouleau. When this happens the blood will trip up faster in the tube.
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