Opiate receptors?

in an overdose situation what does heroin do besides overstimulate the opiate receptors (depresses breathing)?
Meaning what are heroin's toxic effects inside and outside the CNS?

Answers:    Other than the intact "not breathing" thing, opiates will slow heart rate and drop blood pressure. They will also end in pruritis (itching), urinary retention and constipation.

We use them a lot contained by anesthesia, where we closely monitor heart rate, rhythm, blood pressure and breathing. (We usually control the breathing.) In awake patients, they can explanation hallucinations or other change in mental status.

Some, close to morphine, can release histamine, and that can lead to hives, bronchospasm and further decrease in blood pressure.

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