Why respiratory alkalosis do not ensue within children surrounded by cases of aspirin poisoning?
Answers:
I'm an MD.
ACUTE aspirin overdose causes acid-base disparity in two ways. To work out this, you need to own a basic command of acidosis/alkilosis in the body. (skip this if you allready know it!)
I'll maintain it simple - there are two places within the body that affect your acid-base balance, your kidneys and your lungs.
Your kidney can increase/decrease the amount of bicarbonate (a pure base) produced or reabsorbed over the course of hours-days. When this goes haywire, its call a METABOLIC acidosis (decreased bicarb) or alkilosis (increased bicarb).
Your lungs can increase/decrease the amount of carbon dioxide (a natural tart when dissolved) that you get rid of within ventilation. By increasing or decreasing your breathing rate, you therefor adjust your body's pH within a matter of minutes. When this go haywire, its called a RESPIRATORY acidosis (decreased or hypo-ventilation) or alkilosis (increased or hyper-ventilation).
When any of these two goes wrong, the body tries to use the other to compensate. So when you enjoy kidney failure, cause a primary metabolic acidosis, the respiratory center in the medulla make you HYPOventilate to breath off smaller quantity CO2 to help compensate. This compensation is swift over a matter of minutes. Vice versa can also go off when the kidney compensate for the lungs, but this takes longer, of a thing of hours-days.
OK! Back to aspirin. Aspirin is unique for a couple reason. First of all it have an entirely different effect if it is one large acute overdose vs a chronicly glorious level. Secondly, within an acute overdose, aspirin causes an acidosis by TWO mechanism - a primary metabolic AND primary respiratory acidosis. How? Aspirin causes metabolic acidosis and simultaneously inhibites the medulla's respiratory drive center cause respiratory acidosis. This is seen within adults as well as children. Children should use tylenol instead of aspirin, however, due to its loose association beside a terrible desease particular as Reye's Sydrome.
BOTTOM LINE - Aspirin blocks compensatory respiratory alkalosis in children and adults by suppressing our medullary respiratory drive center.
Acute Aspirin Toxicity:
* Uncompensated Respiratory Acidosis
* Cause: Huge amout of Aspirin cause medullary inhibition --> Hypoventilaion --> increase of Serum CO2 --> respiratory acidosis
* Moreover, the kidneys are normally excreting bicarbonate products (alkali within nature) --> more acidosis (metabolic now).
* This leads to severe uncompensated acidosis
Chronic Aspirin Toxicity:
* Compensated Respiratory Alkalosis
* Cause: Mild heap of Aspirin over time causes medullary stimulation > hyperpnea --> excretion of more CO2 --> fade of Serum CO2 --> respiratory alkalosis
* However, the kidneys are normally excreting bicarbonate products (alkali surrounded by nature) --> neutralization of the present alkalosis (compensation) --> pH back to regular
Hope this helps.
Perhaps they do not hyperventilate but become neurologically depressed instead and any hypo ventilate , become apneic or do not counter.
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