Help my homework around BLOOD !!?

what prevent blood flowing in blood vessel from clotting ?


Answers:    fibrin mesh
A number of factors hang on to a clot from forming when blood vessels remain intact.

Collagen, tissue factor and VWF remain out of contact the blood due to the intact endothelium.
Prostacyclin (prostaglandin I2) is synthesized by the intact endothelium and prevents platelet activation. Nitric oxide is also released below these conditions, which keeps the blood vessel dilated TFPI (tissue factor pathway inhibitor, which is released from the endothelium, binds to tissue factor and keeps it still. Thrombomodulin binds thrombin and protein C, which activates protein C, which contained by turn inactives important clotting factor in the blood. heparan proteoglycan (heparin) binds and activate anti-thrombin, which in turn inactivates thrombin.
Fibrinogen have to be activated for blood to clot. Sources of fibrinogen activators would be things resembling collagen from damaged vessel walls.

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