What is the differecnce between cetirizine hydrochloride/dihydrochlo. & is 1 more efficient than the other?
Answers:
things suit people differently try to find what suits you,
not sure just about the second one but i find cetrizine very influential
I'm a pharm tech. This is how I understand it. Claritin, which be fomerly a prescription only antihistamine, lost it's pattent. Once this happen any manufacturer can produce this medication. Instead of keeping claritin as rx lone, it was approved as OTC friendly. Therefore Schering-Plough (it's manufacturer) begin losing money. They solved this problem by creating RX only Clarinex.
The generic signature for Claritin is Loratadine
The generic name for Clarinex is Desloratadine
Schering Plough slightly altered the chemical lipstick of loratadine. They added something that doesn't effect the key ingredients of Claritin, nonetheless because of this SLIGHT difference in chemical foundation; they are able to brand this drug as CLARINEX. EVEN though they are basicly duplicate pill.
So to answer your question roughly speaking certirizine (zyrtec), the hydrochloride was altered and made into DIhydrochloride so a different businesswoman could produce it as BETTER than hydrochloride and charge you $10 more..
It's just different salt of the same parent drug, cetirizine.
Neither is more efficient than the other: the cetirizine is the active constituent, not the hydrochloride.
By the way, I found cetirizine forceful, but terribly sedating; I be a zombie after a week on it. I get along beside fexofenidine better, but that's the vagaries of my personal metabolism, I suppose.
Drugs do not readily enter the human blood stream. Sometimes they need to be altered so that they become river soluble, get out of the stomach, into the blood and in consequence reach lots of the human body. Adding HCl is the simplest course of doing it. Adding more HCl might make it marginally better at getting into the bloodstream, but I doubt it. I would agree that its a bearing of getting around the patent so they can market it as their own.
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